Helmholtz Centre for Environmental Research UFZ, Department of Analytical Environmental Chemistry, Permoserstr. 15, D-04318 Leipzig, Germany; University of Halle-Wittenberg, Institute of Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle, Germany.
Helmholtz Centre for Environmental Research UFZ, Department of Analytical Environmental Chemistry, Permoserstr. 15, D-04318 Leipzig, Germany.
Chemosphere. 2018 May;199:174-181. doi: 10.1016/j.chemosphere.2018.02.026. Epub 2018 Feb 6.
In this work we combine partition coefficients between water and membrane lipid, storage lipid, the plasma protein albumin as well as structural protein with the tissue dependent fraction of the respective phases in order to obtain a clearer picture on the relevance of various biological tissues for the bioaccumulation of 31 organic anions. Most of the partition coefficients are based on experimental data, supplemented by some predicted ones. The data suggest that the plasma protein, albumin, will be the major sorption matrix in mammals. Only small fractions of the studied chemicals will occur freely dissolved in an organism. For the investigated acids with pKa <5, partitioning is dominated by the ionic species rather than the corresponding neutral species. Bioconcentration in fish is not expected to occur for many of these acids unless pH in the aqueous environment is low or specific sorption mechanisms are relevant. In contrast, biomagnification in terrestrial mammals would be expected for most organic anions if they are not sufficiently metabolized. We conclude that sorption is important for the toxicokinetics of ionizable organic chemicals and the dominating sorbing matrices are quite different from those for neutral species.
在这项工作中，我们将水和膜脂质、储存脂质、血浆蛋白白蛋白以及与各相应相的组织相关的结构蛋白之间的分配系数与各种有机阴离子的生物积累的相关性结合起来，以更清楚地了解各种生物组织的相关性。大多数分配系数基于实验数据，辅以一些预测数据。这些数据表明，血浆蛋白白蛋白将是哺乳动物中主要的吸附基质。在生物体中，只有一小部分研究的化学物质将以自由溶解的形式存在。对于研究的 pKa <5 的酸，分配主要由离子物种决定，而不是相应的中性物种。除非水环境中的 pH 值较低或存在特定的吸附机制，否则这些酸中的许多物质不太可能在鱼类中发生生物浓缩。相比之下，如果这些有机阴离子不能被充分代谢，它们在陆地哺乳动物中就会发生生物放大。我们得出结论，吸附对于可离子化有机化学物质的毒代动力学很重要，并且主要的吸附基质与中性物质的吸附基质有很大的不同。
