Laboratory of Virology, Institute of Biomedical Science, ICBIM, Federal University of Uberlândia, Avenida Amazonas, Bloco 4C - sala 216. Umuarama, Uberlândia, MG, CEP: 38405-302, Brazil.
Genomics Study Laboratory, São Paulo State University, São José do Rio Preto, SP, Brazil.
Virol J. 2018 Feb 13;15(1):34. doi: 10.1186/s12985-018-0945-3.
Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of HCV infection; however, a number of drugs are available for the treatment of infection. The availability of direct-acting antivirals (DAAs) has dramatically improved therapeutic options for HCV genotype 1. However, the high costs and potential for development of resistance presented by existing treatment demonstrate the need for the development of more efficient new antivirals, or combination of therapies that target different stages of the viral lifecycle. Over the past decades, there has been substantial study of compounds extracted from plants that have activity against a range of microorganisms that cause human diseases. An extensive variety of natural compounds has demonstrated antiviral action worldwide, including anti-HCV activity. In this context, plant-derived compounds can provide an alternative approach to new antivirals. In this review, we aim to summarize the most promising plant-derived compounds described to have antiviral activity against HCV.
丙型肝炎病毒（HCV）感染是全球公共卫生的负担，据估计，全球有 1.85 亿人正在或曾经感染过 HCV。目前尚无有效的 HCV 疫苗用于预防感染；然而，已有多种药物可用于治疗感染。直接作用抗病毒药物（DAAs）的出现极大地改善了 HCV 基因型 1 的治疗选择。然而，现有治疗方法的高成本和潜在耐药性表明，需要开发更有效的新型抗病毒药物，或针对病毒生命周期不同阶段的联合治疗方案。在过去的几十年中，人们对具有抗多种引起人类疾病的微生物活性的植物提取物进行了大量研究。在全球范围内，广泛的天然化合物已被证明具有抗病毒作用，包括抗 HCV 活性。在这种情况下，植物来源的化合物可以为新型抗病毒药物提供替代方法。在这篇综述中，我们旨在总结描述的最有前途的具有抗 HCV 活性的植物来源化合物。
