食管癌中高甲基化的早期诊断潜力
Early diagnostic potential of hypermethylation in esophageal cancer.
作者信息
Wang Bujiang, Song Haojun, Jiang Haizhong, Fu Yangbo, Ding Xiaoyun, Zhou Chongchang
机构信息
Department of Gastroenterology, Laboratory of Digestive Diseases, Ningbo First Hospital, Ningbo.
Department of Otorhinolaryngology Head and Neck Surgery, Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.
出版信息
Cancer Manag Res. 2018 Feb 1;10:181-198. doi: 10.2147/CMAR.S148677. eCollection 2018.
BACKGROUND
The hypermethylation of APC gene is observed in various cancers, including esophageal cancer (EC). However, the association between APC methylation and the initiation and progression of EC is poorly understood.
PURPOSE AND METHODS
The current study systematically reviewed studies on abnormal methylation of APC in EC and quantitatively synthesized 18 studies by meta-analysis involving 1008 ECs, 570 Barrett's esophagus (BE), and 782 controls.
RESULTS
Our results showed higher methylation of APC in EC (OR = 23.33, < 0.001) and BE (OR = 9.34, < 0.001) than in normal controls. Whereas APC methylation in EC was similar to that in BE ( = 0.052), it was not associated with tumor stage ( = 0.204). Additionally, APC methylation was not significantly associated with overall survival (OS) and relapse-free survival (RFS) in patients with EC. The performance of APC methylation for the detection of EC and BE achieved areas under the receiver operating characteristic curves of 0.94 and 0.88, respectively.
CONCLUSION
Our results imply that APC methylation detection is a potential diagnostic biomarker for EC and BE.
背景
在包括食管癌（EC）在内的多种癌症中均观察到APC基因的高甲基化。然而，APC甲基化与EC发生发展之间的关联尚不清楚。
目的与方法
本研究系统回顾了关于EC中APC异常甲基化的研究，并通过荟萃分析对18项研究进行了定量综合分析，这些研究涉及1008例EC患者、570例巴雷特食管（BE）患者和782例对照。
结果
我们的结果显示，与正常对照相比，EC（OR = 23.33，<0.001）和BE（OR = 9.34，<0.001）中APC的甲基化水平更高。虽然EC中APC的甲基化水平与BE相似（P = 0.052），但与肿瘤分期无关（P = 0.204）。此外，APC甲基化与EC患者的总生存期（OS）和无复发生存期（RFS）无显著关联。APC甲基化检测EC和BE的受试者工作特征曲线下面积分别为0.94和0.88。
结论
我们的结果表明，APC甲基化检测是EC和BE潜在的诊断生物标志物。
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