Bakhtiari Sedigheh, Sehatpour Marziye, Mortazavi Hamed, Bakhshi Mahin
Oral Medicine Department, Dental Faculty, Shahid Beheshti University of Medical Sciences, Islamic Republic of Iran.
Clujul Med. 2018;91(1):27-36. doi: 10.15386/cjmed-748. Epub 2018 Jan 15.
Adverse reaction to medication is common and may have a variety of clinical manifestations in the oral cavity. The present review paper aimed to describe adverse drug reactions (ADRs) which might be encountered by dental practitioners in every discipline.
In this narrative review article, the specialized databases such as PubMed, PubMed Central, MEDLINE, EBSCO, Science Direct, Scopus, and reference books from the years 2000-2016 were used to find relevant documents by using MeSH terms: Adverse Drug Reaction, Drug induced, Medication Related, Mouth, Oral Manifestation, Tooth, Hard Tissue, Soft Tissue.
The data were categorized in 4 groups as follows: saliva and salivary glands involvement, soft tissue (mucosal) involvement, hard tissue involvement, and non specific conditions (taste disorders, halitosis, neuropathies, movement disturbances, and infection). Most articles were about the adverse effect of drugs on the function of salivary glands, which often cause a decrease in saliva secretion. Other reactions were less common; meanwhile, the side effect of bisphosphonate was increasing in the alveolar bone, because of its unlimited prescription.
Oral health care providers should be familiar with such events, as they will be confronted with them in their practice.
药物不良反应很常见，在口腔中可能有多种临床表现。本综述旨在描述各牙科领域从业者可能遇到的药物不良反应（ADR）。
在这篇叙述性综述文章中，使用了诸如PubMed、PubMed Central、MEDLINE、EBSCO、ScienceDirect、Scopus等专业数据库以及2000 - 2016年的参考书，通过使用医学主题词（MeSH）：药物不良反应、药物诱导、药物相关、口腔、口腔表现、牙齿、硬组织、软组织来查找相关文献。
数据分为以下4组：唾液及唾液腺受累、软组织（黏膜）受累、硬组织受累以及非特异性情况（味觉障碍、口臭、神经病变、运动障碍和感染）。大多数文章是关于药物对唾液腺功能的不良影响，这通常会导致唾液分泌减少。其他反应则较少见；与此同时，由于双膦酸盐的无节制处方，其在牙槽骨中的副作用正在增加。
口腔保健提供者应熟悉此类情况，因为他们在实践中会遇到这些情况。
