Du Jinlei, Wang Min, Wu Xiaoling, Yu Tianbo, Zhang Jiquan, Wu Jimin
Department of Critical Care Medicine, Zigong Fourth People's Hospital, Zigong, China.
Department of Critical Care Medicine, Deyang People's Hospital, Deyang, China.
Front Med (Lausanne). 2025 Aug 18;12:1623226. doi: 10.3389/fmed.2025.1623226. eCollection 2025.
To investigate the prevalence of sialorrhea in orally intubated patients and systematically analyze its influencing factors.
A cross-sectional study was conducted from March 15 to 31, 2025, involving 40 tertiary general hospitals across 10 prefecture-level cities in Sichuan Province, including Chengdu, Zigong, and Mianyang. The investigation assessed the current status of sialorrhea in patients undergoing oral endotracheal intubation.
A total of 453 questionnaires were collected, of which 440 were valid, yielding an effective response rate of 97.0%. Statistical analysis revealed that the incidence rate of sialorrhea among orally intubated patients was 27.27%. Multivariate logistic regression analysis identified the following as independent risk factors for sialorrhea: Body Mass Index (BMI) (OR = 1.365, 95% CI: 1.217-1.531), Smoking (OR = 8.944, 95% CI: 4.272-18.727), Number of Combined Functional Impairment Systems (OR = 2.844, 95% CI: 1.814-4.460), Combined Oral Disease (OR = 2.578, 95% CI: 1.240-5.359), and Neurological Diseases (OR = 4.040, 95% CI: 1.053-15.507). A restricted cubic spline analysis further demonstrated that when BMI exceeds 22.785, the risk of developing sialorrhea increases significantly.
The incidence of sialorrhea in orally intubated patients is at a moderate-to-low level. This condition is closely associated with elevated BMI, smoking, a higher number of combined functional impairments, the presence of oral disease, and underlying nervous system disorders.
调查经口插管患者流涎的患病率，并系统分析其影响因素。
于2025年3月15日至31日进行了一项横断面研究，涉及四川省10个地级市的40家三级综合医院，包括成都、自贡和绵阳。该调查评估了经口气管插管患者流涎的现状。
共收集问卷453份，其中有效问卷440份，有效应答率为97.0%。统计分析显示，经口插管患者流涎的发生率为27.27%。多因素logistic回归分析确定以下因素为流涎的独立危险因素：体重指数（BMI）（OR = 1.365，95%CI：1.217 - 1.531）、吸烟（OR = 8.944，95%CI：4.272 - 18.727）、合并功能障碍系统数量（OR = 2.844，95%CI：1.814 - 4.460）、合并口腔疾病（OR = 2.578，95%CI：1.240 - 5.359）和神经系统疾病（OR = 4.040，95%CI：1.053 - 15.507）。受限立方样条分析进一步表明，当BMI超过22.785时，发生流涎的风险显著增加。
经口插管患者流涎的发生率处于中低水平。这种情况与BMI升高、吸烟、合并功能障碍数量较多、口腔疾病的存在以及潜在的神经系统疾病密切相关。
