Stefíková H, Sovcíková E, Bronis M
Physiol Bohemoslov. 1986;35(3):227-32.
At present, two main circadian oscillators are known, responsible for the rhythm of body temperature (BT) and body activity. Their independence has been demonstrated by the dissociation of these two rhythms in people during long-term isolation. In order to ascertain the circadian rhythm (CR) of heart rate variability (HRV), the ECG was recorded in 24 healthy awake men every two hours in the sitting position, from Friday 5 p.m. to Monday 6 a.m., who were maintained on a standard regime. One hundred consecutive RR intervals in every ECG were measured and from these 11 selected indicators of HRV were computed. Chronograms from the means of BT, respiratory rate, and electrical skin resistance showed pronounced CR with acrophases at 6 to 8 p.m. "Frequency" parameters of HRV, especially the frequency of reversal points, behaved similarly. CR in the remaining 7 "amplitude" parameters was also detected in individual persons, but their acrophases were different, and averaged chronograms mostly exhibited a flat course. The study has shown that there are at least two circadian components of HRV: the first phase has the CR synchronized with BT and is interindividually more homogeneous; the second phase is synchronized with body activity rhythm and is interindividually heterogeneous. On this basis, three equal subgroups of subjects arose, tentatively called afternoon, night, and forenoon types, respectively, in accordance with information about their preference for working and sleeping.
目前，已知有两个主要的昼夜节律振荡器，负责体温（BT）和身体活动的节律。这两种节律在长期隔离的人群中相互分离，从而证明了它们的独立性。为了确定心率变异性（HRV）的昼夜节律（CR），对24名健康清醒男性进行了研究，他们在标准作息下，于周五下午5点至周一上午6点，每隔两小时以坐姿记录心电图。测量每份心电图中连续100个RR间期，并据此计算出11项HRV指标。体温、呼吸频率和皮肤电阻均值的时间序列图显示出明显的昼夜节律，峰值相位在下午6点至8点。HRV的“频率”参数，尤其是转折点频率，表现类似。在个体中也检测到其余7项“振幅”参数的昼夜节律，但其峰值相位不同，平均时间序列图大多呈现平坦趋势。研究表明，HRV至少有两个昼夜节律成分：第一阶段的昼夜节律与体温同步，个体间更为一致；第二阶段与身体活动节律同步，个体间存在差异。在此基础上，根据受试者对工作和睡眠的偏好信息，初步出现了三个相等的亚组，分别称为下午型、夜间型和上午型。
