Bakemeier R F, Hildreth N G, Ryan D H
Radiat Res. 1986 Sep;107(3):367-74.
One-hundred and fifty-three subjects who were irradiated in infancy for an alleged enlarged thymus and 51 controls were studied to quantify the phenotypically different subpopulations of peripheral blood lymphocytes and immunoglobulins. These subjects were selected from a larger cohort which has been followed prospectively since the early 1950s. Previous studies of this cohort have shown a radiation dose-related increased risk of thyroid carcinomas and adenomas in the irradiated group as well as a recent excess of various extrathyroid neoplasms. In this substudy, no significant differences in lymphocyte subpopulations or immunoglobulin levels were observed between the irradiated and control groups. These findings support a hypothesis that the radiation-related excess of neoplasms in this cohort may have resulted from direct cellular damage with subsequent mutations rather than impaired immune function.
对153名在婴儿期因胸腺肿大而接受辐射的受试者和51名对照者进行了研究，以量化外周血淋巴细胞和免疫球蛋白在表型上不同的亚群。这些受试者选自一个自20世纪50年代初以来一直进行前瞻性跟踪的更大队列。此前对该队列的研究表明，辐射组中甲状腺癌和腺瘤的发病风险与辐射剂量相关增加，以及近期各种甲状腺外肿瘤的增多。在这项子研究中，辐射组和对照组之间在淋巴细胞亚群或免疫球蛋白水平上未观察到显著差异。这些发现支持了这样一种假设，即该队列中与辐射相关的肿瘤增多可能是由于直接的细胞损伤及随后的突变，而非免疫功能受损所致。
