Lee Ki Hong, Shin Min Ho, Park Hyung Wook, Cho Jeong Gwan, Kweon Sun Seog, Lee Young Hoon
Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Korea.
Korean Circ J. 2018 Feb;48(2):159-167. doi: 10.4070/kcj.2017.0187.
We aimed to investigate the association between serum parathyroid hormone (PTH) levels and the prevalence of atrial fibrillation (AF) in a population based study.
This study included a total of 9,007 community-dwelling Koreans aged 50 years and over who were enrolled in the Dong-gu study from 2007 to 2010. Electrocardiograms were recorded from the subjects using the HP-PageWriter 200 M1771A. All potential cases of AF were determined by 2 cardiologists. PTH concentration was measured by a chemiluminescent microparticle immunoassay. Multiple logistic regression analysis was used to evaluate the relationship between the quartiles of PTH and AF, adjusting for potential confounders.
The prevalence of AF was 2.41% in males and 0.9% in females and increased with advanced age in both genders. The median and interquartile range (IQR) of serum PTH was 39.5 pg/mL (IQR, 30.6-50.8), which was significantly higher in patients with AF than in patients without AF (p<0.001). The prevalence of AF increased with increasing PTH quartile (0.8%, 0.9%, 1.6%, and 2.8% in the lowest, second, third, and highest PTH quartiles, respectively; p<0.001). Multivariable logistic analysis adjusted for cardiovascular risk factors showed the highest quartile of serum PTH levels was associated with a higher prevalence of AF than the lowest quartile (odds ratio, 3.34; 95% confidence interval, 1.93-5.78).
Higher levels of serum PTH were associated with higher prevalence of AF. Further studies are needed to determine whether this association is present in other populations and in a prospective study setting.
在一项基于人群的研究中，我们旨在探究血清甲状旁腺激素（PTH）水平与心房颤动（AF）患病率之间的关联。
本研究共纳入了9007名年龄在50岁及以上的韩国社区居民，他们于2007年至2010年参与了东谷研究。使用惠普PageWriter 200 M1771A为受试者记录心电图。所有潜在的房颤病例均由两名心脏病专家确诊。采用化学发光微粒子免疫分析法测量PTH浓度。运用多因素logistic回归分析评估PTH四分位数与房颤之间的关系，并对潜在混杂因素进行校正。
男性房颤患病率为2.41%，女性为0.9%，且两性患病率均随年龄增长而升高。血清PTH的中位数及四分位数间距（IQR）为39.5 pg/mL（IQR，30.6 - 50.8），房颤患者的该值显著高于无房颤患者（p<0.001）。房颤患病率随PTH四分位数升高而增加（最低、第二、第三和最高PTH四分位数组的患病率分别为0.8%、0.9%、1.6%和2.8%；p<0.001）。校正心血管危险因素后的多变量logistic分析显示，血清PTH水平最高四分位数组的房颤患病率高于最低四分位数组（比值比，3.34；95%置信区间，1.93 - 5.78）。
血清PTH水平较高与房颤患病率较高相关。需要进一步研究以确定这种关联在其他人群以及前瞻性研究环境中是否存在。
