a Department of Pharmaceutical Technology, College of Pharmacy , University of Tanta , Tanta , Egypt.
Pharm Dev Technol. 2019 Feb;24(2):157-165. doi: 10.1080/10837450.2018.1441302. Epub 2018 Feb 23.
The fluidity of vesicular membrane affects vesicular transdermal drug delivery. Essential oils can be located in vesicular membrane imparting flexibility and influencing transdermal delivery. Accordingly, the objective was to investigate the effect of incorporation of essential oils in niosomes on felodipine transdermal delivery. Rigid niosomes comprising Span 60 with cholesterol (2:1, w/w) were used with clove, eucalyptus or lemon oils being incorporated in the vesicles at increasing concentrations. The vesicle size and shape was monitored using scanning electron microscopy. Thermal analysis was used to monitor the thermal behavior. Drug entrapment efficiency, release and skin permeation were monitored. Niosomes were spherical with size ranging from 279 to 345 nm. The drug entrapment ranged from 97.9 to 98.8%. Thermal analysis confirmed the existence of oils within vesicular membrane and highlighted the membrane fluidizing effect. Drug release depended on the oil with clove oil or eucalyptus oil showing a trend of increased drug release compared with plain niosomes. In contrast, lemon oil reduced drug release rate. Skin permeation study reflected the superiority of oil containing niosomes. The results correlated with the fluidizing and penetration enhancing effects of oils. The study introduced essential oils as potential niosomes fluidizing agents for enhanced transdermal drug delivery.
囊泡膜的流动性影响囊泡经皮药物传递。精油可以位于囊泡膜中，赋予其柔韧性并影响经皮传递。因此，本研究旨在考察将精油纳入脂质体对非洛地平经皮传递的影响。刚性脂质体由 Span 60 与胆固醇（2:1，w/w）组成，将丁香、桉树或柠檬油以递增浓度纳入囊泡中。使用扫描电子显微镜监测囊泡的大小和形状。使用热分析监测热行为。监测药物包封效率、释放和皮肤渗透。脂质体呈球形，粒径为 279 至 345nm。药物包封率为 97.9%至 98.8%。热分析证实了油存在于囊泡膜内，并强调了膜的流变性。药物释放取决于油，与普通脂质体相比，丁香油或桉树油显示出增加药物释放的趋势。相比之下，柠檬油降低了药物释放速率。皮肤渗透研究反映了含油脂质体的优越性。结果与油的流变性和渗透增强作用相关。该研究将精油引入为增强经皮药物传递的潜在脂质体流变性增强剂。
