Fukuno S, Nagai K, Yoshida S, Suzuki H, Konishi H
Pharmazie. 2016 Sep 1;71(9):530-532. doi: 10.1691/ph.2016.6611.
5-Fluorouracil (5-FU) is a pyrimidine analog widely used for the treatment of various cancers, but often causes hepatic damage in clinical practice. In this study, we examined the influence of taurine on 5-FU-induced hepatotoxicity in mice with respect to changes in oxidative stress. Elevations in the aspartate aminotransferase and alanine aminotransferase serum levels after 5-FU administration were significantly suppressed in a dosedependent manner by concurrent treatment with taurine. The activity of superoxide dismutase and reduced glutathione content in the liver were significantly decreased following treatment with 5-FU alone, but these changes were markedly inhibited by the administration of taurine. Our findings suggest that taurine protects against 5-FU-induced hepatotoxicity by suppressing oxidative stress.
5-氟尿嘧啶（5-FU）是一种广泛用于治疗各种癌症的嘧啶类似物，但在临床实践中常导致肝损伤。在本研究中，我们从氧化应激变化方面研究了牛磺酸对5-FU诱导的小鼠肝毒性的影响。5-FU给药后，天冬氨酸转氨酶和丙氨酸转氨酶血清水平的升高通过与牛磺酸同时治疗以剂量依赖性方式得到显著抑制。单独用5-FU治疗后，肝脏中超氧化物歧化酶的活性和还原型谷胱甘肽含量显著降低，但这些变化被牛磺酸给药显著抑制。我们的研究结果表明，牛磺酸通过抑制氧化应激来预防5-FU诱导的肝毒性。
