Keshavarzi Majid, Naraki Karim, Razavi Bibi Marjan, Hosseinzadeh Hossein
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan;398(1):203-230. doi: 10.1007/s00210-024-03331-0. Epub 2024 Aug 14.
Taurine, a non-essential amino acid produced from cysteine, is abundant in body tissues and blood plasma. It plays vital roles in growth, osmosis, lipid metabolism, and neurohormonal modulation. Taurine has antioxidant, anti-apoptotic, and anti-inflammatory properties, and its deficiency can lead to various diseases including cardiovascular, diabetic, renal, and liver disorders. This report provides a comprehensive review of the functional properties of taurine in counteracting pharmaceutical-induced side effects. A search across databases such as Scopus, PubMed, MEDLINE, and Web of Science yielded 109 articles, of which 75 were included in the study. These results suggest that the protective effects of taurine involve mechanisms such as influencing pathways of Nrf2/OH-1, PI3-kinase/AKT and ERK2, boosting antioxidants (SOD, GPx and CAT), and suppression of inflammatory cytokines (TNF-α, IL-1β and IL-6). Overall, supplementation with taurine along with medications with significant side effects may mitigate these effects and enhance their efficacy. Further investigation of the interactions between taurine and other nutrients or compounds may provide insights into synergistic effects and novel therapeutic approaches.
牛磺酸是一种由半胱氨酸产生的非必需氨基酸，在人体组织和血浆中含量丰富。它在生长、渗透、脂质代谢和神经激素调节中发挥着重要作用。牛磺酸具有抗氧化、抗凋亡和抗炎特性，其缺乏会导致包括心血管、糖尿病、肾脏和肝脏疾病在内的各种疾病。本报告全面综述了牛磺酸在对抗药物引起的副作用方面的功能特性。在Scopus、PubMed、MEDLINE和Web of Science等数据库中进行检索，共获得109篇文章，其中75篇被纳入本研究。这些结果表明，牛磺酸的保护作用涉及影响Nrf2/OH-1、PI3激酶/AKT和ERK2通路、增强抗氧化剂（超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶）以及抑制炎性细胞因子（肿瘤坏死因子-α、白细胞介素-1β和白细胞介素-6）等机制。总体而言，在使用有显著副作用的药物时补充牛磺酸可能会减轻这些副作用并提高其疗效。进一步研究牛磺酸与其他营养素或化合物之间的相互作用可能会为协同效应和新的治疗方法提供见解。
