Scott J
J Biol Buccale. 1979 Dec;7(4):341-52.
One submandibular gland from each of 33 necropsies on children aged between birth and 14 years was examined histologically. A simple point-counting method established the volume fractions of various component tissues of the glands and these were compared between five age groups. Below 30 days of age acini and ducts were often immature and widely separated by abundant, vascular, connective tissue. After six months of age glandular structure was more compact with little intralobular connective tissue. Lymphocytic foci were numerous in many of the glands from children aged over six months with a prevalence higher than that previously established for young adults. Consolidated intraductal deposits were found in just under half the glands, mostly after the age of six months. The mean volume proportion of acinar tissue was 43% in the age group 0-30 days but had increased to 64% in the 6 month -- 2 year age group. Over the same period there were reductions in the mean proportional volumes of ducts, vascular and connective tissues. After the age of two years changes in the volume proportions of component tissues were not significant. The developmental and growth-associated changes of the present investigation were opposite in direction to the ageing changes which previous studies have shown occur over the whole of adult life. Moreover, the point at which reversal occurs seems to be in early adult life rather than in childhood.
对33例出生至14岁儿童尸检的每例标本取下颌下腺1个，进行组织学检查。采用简易计数法确定下颌下腺各组成组织的体积分数，并在5个年龄组间进行比较。30日龄以下时，腺泡和导管常不成熟，被丰富的血管性结缔组织广泛分隔。6月龄后，腺结构更紧密，小叶内结缔组织较少。6月龄以上儿童的许多下颌下腺中有大量淋巴细胞灶，其发生率高于此前对年轻成人所确定的发生率。近半数下颌下腺发现有导管内沉积物，大多在6月龄以后。0～30日龄组腺泡组织的平均体积比例为43%，但在6月龄至2岁年龄组已增至64%。同期，导管、血管和结缔组织的平均比例体积减少。2岁以后，各组成组织的体积比例变化不明显。本研究中与发育和生长相关的变化方向与先前研究显示的整个成年期发生的衰老变化相反。此外，发生逆转的时间点似乎在成年早期而非儿童期。
