Rother P, Peil J, Schmerling S, Mahn G, Böttger O
Anat Anz. 1982;151(1):29-40.
Morphometric examinations were made on hematoxylin-stained paraffin sections of 43 human submaxillary glands, in order to determine and describe histological changes of this organ during the aging thereof. The number of fat cells per unit area increases in the first decades, whereas that of the striated ducts decreases. Obviously, striated ducts differentiate earlier than serous acini, with the former thus being less subject to involution with aging than the latter. In old age, the nuclei of the epithelial cells of serous acini and striated ducts are characterized by the formation of certain classes of size, of which the association with polyploidization is, however, questionable. In a 44-year-old male, differences in the size of nuclei between different striated ducts of one section, which were due perhaps to functional peculiarities, indicated the existence of inactive and active glandular regions. The volume density of serous acini decreases continuously in the course of life, while that of the striated ducts decreases in the first decennia only. On the other hand, there was observed a continuous increase in the volume density of fat cells in the entire course of life and an increase of the volume density of connective tissue in the second half of life. The mucous fractions were observed to increase up through the fifth decade of life, after which they were seen to decrease continuously.
为了确定并描述人类颌下腺在衰老过程中的组织学变化，对43例人类颌下腺苏木精染色石蜡切片进行了形态计量学检查。在生命的最初几十年里，单位面积内脂肪细胞的数量增加，而纹状管的数量减少。显然，纹状管比浆液性腺泡分化得更早，因此前者在衰老过程中比后者更不易发生退化。在老年时，浆液性腺泡和纹状管上皮细胞核的特征是形成了某些大小类别，然而，这些大小类别与多倍体化的关联值得怀疑。在一名44岁男性中，同一切片中不同纹状管之间细胞核大小的差异可能是由于功能特性所致，这表明存在无活性和有活性的腺区。浆液性腺泡的体积密度在生命过程中持续下降，而纹状管的体积密度仅在最初几十年下降。另一方面，在整个生命过程中观察到脂肪细胞的体积密度持续增加，在生命的后半期结缔组织的体积密度增加。黏液成分在生命的第五个十年之前一直增加，之后则持续减少。
