van Helmond Noud, Timmerman Hans, Olesen Søren S, Drewes Asbjørn M, Kleinhans Joris, Wilder-Smith Oliver H, Vissers Kris C, Steegers Monique A
Department of Anesthesiology, Pain, and Palliative Medicine, Radboud University Medical Center;
Department of Anesthesiology, Pain, and Palliative Medicine, Radboud University Medical Center.
J Vis Exp. 2018 Jan 18(131):56918. doi: 10.3791/56918.
Chronic pain following surgery, persistent postsurgical pain, is an important highly prevalent condition contributing to significant symptom burden and lower quality of life. Persistent postsurgical pain is relatively refractory to treatment hence generating a high need for preventive strategies and treatments. Therefore, the identification of patients at risk of developing persistent pain is an area of active ongoing research. Recently it was demonstrated that peri-operative disruptions in central pain processing may be able to predict persistent postsurgical pain at long term follow-up in breast cancer patients. The aim of the current report is to present a short protocol to obtain pain thresholds to different stimuli at multiple sites and a measure of endogenous analgesia in breast cancer patients. We have used this method successfully in a clinical context and detail some representative results from a clinical study.
手术后的慢性疼痛，即持续性术后疼痛，是一种重要且高度普遍的病症，会导致严重的症状负担和较低的生活质量。持续性术后疼痛相对难以治疗，因此对预防策略和治疗的需求很高。所以，识别有发展为持续性疼痛风险的患者是一个正在积极进行研究的领域。最近有研究表明，乳腺癌患者围手术期中枢疼痛处理的中断可能能够预测长期随访时的持续性术后疼痛。本报告的目的是介绍一个简短的方案，用于获取乳腺癌患者多个部位对不同刺激的疼痛阈值以及内源性镇痛的测量方法。我们已在临床环境中成功使用了这种方法，并详细介绍了一项临床研究的一些代表性结果。
