原发性和继发性情感障碍患者对促甲状腺激素释放激素（TRH）和促黄体生成素释放激素（LRH）给药的β-内啡肽和β-促脂素反应异常。

Abnormal beta-endorphin and beta-lipotropin responses to TRH and LRH administration in primary and secondary affective disorders.

作者信息

Brambilla F, Petraglia F, Facchinetti F, Genazzani A R

出版信息

Acta Endocrinol (Copenh). 1986 Aug;112(4):481-6. doi: 10.1530/acta.0.1120481.

DOI:10.1530/acta.0.1120481

Abstract

Anomalous anterior pituitary hormone responses to acute administration of TRH and LRH have previously been observed in patients with primary affective disorders (PAD), with TRH eliciting GH, FSH and LH rises, and LRH eliciting GH and Prl rises. We examined whether the same unusual responses were present also for beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) in 15 PAD patients, in 9 patients with secondary affective disorders (SAD), and in 7 controls. TRH (500 micrograms iv) elicited rises of beta-EP plasma levels in 5 PAD and 2 SAD patients, and of beta-LPH in 4 PAD and 3 SAD patients. LRH (150 micrograms iv) elicited rises of plasma beta-EP levels in 2 PAD and 2 SAD patients, and of beta-LPH in 5 PAD and 2 SAD patients. No rises of beta-EP and beta-LPH plasma levels were observed in PAD patients after saline administration, nor in the controls after TRH, LRH or saline administration.

摘要

先前在原发性情感障碍（PAD）患者中观察到垂体前叶激素对急性注射促甲状腺激素释放激素（TRH）和促黄体激素释放激素（LRH）的异常反应，TRH可引起生长激素（GH）、促卵泡激素（FSH）和促黄体激素（LH）升高，LRH可引起GH和催乳素（Prl）升高。我们检测了15例PAD患者、9例继发性情感障碍（SAD）患者和7例对照者中β-内啡肽（β-EP）和β-促脂素（β-LPH）是否也存在同样的异常反应。静脉注射TRH（500微克）使5例PAD患者和2例SAD患者的血浆β-EP水平升高，4例PAD患者和3例SAD患者的β-LPH水平升高。静脉注射LRH（150微克）使2例PAD患者和2例SAD患者的血浆β-EP水平升高，5例PAD患者和2例SAD患者的β-LPH水平升高。PAD患者注射生理盐水后，以及对照组注射TRH、LRH或生理盐水后，均未观察到血浆β-EP和β-LPH水平升高。