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新生儿鹑鸡肠球菌脑膜炎首例病例报告:文献综述

The first case report of Enterococcus gallinarum meningitis in neonate: A literature review.

作者信息

Li Xiaoquan, Fan Shujuan, Lin Xiaojie, Liu Li, Zheng Jie, Zhou Xihui, Heep Axel

机构信息

Department of Neonatology Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China Neonatal Unit, North Bristol NHS Trust, Bristol, The United Kingdom.

出版信息

Medicine (Baltimore). 2018 Feb;97(7):e9875. doi: 10.1097/MD.0000000000009875.

Abstract

RATIONALE

Enterococcus gallinarum meningitis (EGM) is rarely found in normal adults and even rarer in children. To our knowledge, EGM in neonate has not been reported previously.

PATIENTS CONCERNS

Here we reported the first case of EGM in neonate. Prolonged fever was the only manifestation for the case after admission.

DIAGNOSES

Cerebrospinal fluid cultures showed that the isolate was Enterococcus gallinarum and sensitive to linezolid.

INTERVENTIONS

Ceftriaxone, beta lactam type, and vancomycin were used respectively, but not effective.

OUTCOMES

The temperature went down to normal after linezolid was used and the baby was discharged in good condition in the end.

LESSONS

This case indicated that EGM could also occur in neonate and fever could be the only obvious manifestation. Thus, the effective antibiotics and adequate duration are very important and linezolid is a potential good choice, especially for vancomycin-resistant patients.

摘要

理论依据

鹑鸡肠球菌脑膜炎(EGM)在正常成年人中很少见,在儿童中更为罕见。据我们所知,此前尚未有新生儿EGM的报道。

患者情况

在此我们报告了首例新生儿EGM病例。入院后该病例唯一的表现是持续发热。

诊断

脑脊液培养显示分离出的菌株为鹑鸡肠球菌,对利奈唑胺敏感。

干预措施

分别使用了头孢曲松(β-内酰胺类)和万古霉素,但均无效。

结果

使用利奈唑胺后体温恢复正常,婴儿最终康复出院。

经验教训

该病例表明EGM也可发生于新生儿,发热可能是唯一明显的表现。因此,有效的抗生素及足够的疗程非常重要,利奈唑胺是一个潜在的良好选择,尤其是对于耐万古霉素的患者。

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