Department of Neurosurgery, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Hubei, P.R. China.
Department of Anesthesiology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Hubei, P.R. China.
Oncol Res. 2018 Sep 14;26(8):1275-1283. doi: 10.3727/096504018X15185735627746. Epub 2018 Feb 14.
The dysregulation of microRNA (miRNA) expression is closely related with tumorigenesis and tumor development in glioblastoma (GBM). In this study, we found that miRNA-598 (miR-598) expression was significantly downregulated in GBM tissues and cell lines. Restoring miR-598 expression inhibited cell proliferation and invasion in GBM. Moreover, we validated that metastasis associated in colon cancer-1 (MACC1) is a novel target of miR-598 in GBM. Restoring MACC1 expression reversed the inhibitory effects of miR-598 overexpression on GBM cells. In addition, miR-598 overexpression suppressed Met/AKT pathway activation in GBM. Our results provided compelling evidence that miR-598 serves tumor-suppressive roles in GBM and that its antioncogenic effects are mediated chiefly through the direct suppression of MACC1 expression and regulation of the Met/AKT signaling pathway. Therefore, miR-598 is a potential target in the treatment of GBM.
miRNA（miRNA）表达失调与脑胶质瘤（GBM）的发生和发展密切相关。在本研究中，我们发现 miRNA-598（miR-598）在 GBM 组织和细胞系中的表达明显下调。恢复 miR-598 的表达可抑制 GBM 中的细胞增殖和侵袭。此外，我们验证了结肠癌转移相关基因 1（MACC1）是 miR-598 在 GBM 中的一个新靶基因。恢复 MACC1 的表达逆转了 miR-598 过表达对 GBM 细胞的抑制作用。此外，miR-598 过表达抑制了 GBM 中 Met/AKT 通路的激活。我们的研究结果为 miR-598 在 GBM 中发挥肿瘤抑制作用提供了有力的证据，其抗肿瘤作用主要是通过直接抑制 MACC1 的表达和调节 Met/AKT 信号通路来实现的。因此，miR-598 是治疗 GBM 的一个潜在靶点。
