Wu Shi-Wu, Wang Yi-Chao, Ci Hong-Fei, Tao Yi-Sheng
Department of Pathology, First Affiliated Hospital of Bengbu Medical College/Department of Pathology, Bengbu Medical College, Bengbu 233004, China.E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2017 Jul 20;37(7):952-956. doi: 10.3969/j.issn.1673-4254.2017.07.18.
To investigate the expressions of vasohibin-1 and MACC1 in lung squamous cell carcinoma (LSCC) and their associations with the clinicopathological characteristics of the patients.
The expressions of vasohibin-1 and MACC1 proteins were examined with immunohistochemistry in 160 LSCC tissues and 80 normal lung tissues.
The positivity rates of vasohibin-1 and MACC1 proteins were 59.4% and 11.3% in LSCC tissues, respectively, which were significantly higher than the rates in normal lung tissues (57.5% and 8.8%, respectively; P<0.05). The expressions of vasohibin-1 and MACC1 proteins were significantly correlated with the tumor grades, lymph node metastasis, and TNM stages (all P<0.05). Spearman correlation analysis indicated a positive correlation between vasohibin-1 expression and MACC1 expressions (P<0.001). Kaplan-Meier survival analysis showed that LSCC patients with a positive expression of vasohibin-1 had significantly shorter overall survival time than those negative for vasohibin-1; the overall survival time was also significantly shorter in patients positive for MACC1 than in those negative for MACC1 (both P<0.05). Multivariate COX regression analysis indicated that positive expressions of vasohibin-1 and MACC1 protein and TNM stage were independent prognostic factors of LSCC.
Aberrant expressions of vasohibin-1 and MACC1 may participate in the development and promote invasion and metastasis of LSCC. The combined detection of vasohibin-1 and MACC1 expression may provide important evidence for predicting the progression and prognosis of LSCC.
探讨血管抑制素-1（vasohibin-1）和结肠癌转移相关基因1（MACC1）在肺鳞状细胞癌（LSCC）中的表达及其与患者临床病理特征的关系。
采用免疫组织化学法检测160例LSCC组织和80例正常肺组织中vasohibin-1和MACC1蛋白的表达。
LSCC组织中vasohibin-1和MACC1蛋白的阳性率分别为59.4%和11.3%，显著高于正常肺组织（分别为57.5%和8.8%；P<0.05）。vasohibin-1和MACC1蛋白的表达与肿瘤分级、淋巴结转移及TNM分期均显著相关（均P<0.05）。Spearman相关性分析显示vasohibin-1表达与MACC1表达呈正相关（P<0.001）。Kaplan-Meier生存分析显示，vasohibin-1表达阳性的LSCC患者总生存时间显著短于vasohibin-1表达阴性的患者；MACC1表达阳性的患者总生存时间也显著短于MACC1表达阴性的患者（均P<0.05）。多因素COX回归分析表明，vasohibin-1和MACC1蛋白阳性表达及TNM分期是LSCC的独立预后因素。
vasohibin-1和MACC1的异常表达可能参与LSCC的发生发展并促进其侵袭和转移。联合检测vasohibin-1和MACC1表达可为预测LSCC的进展及预后提供重要依据。
