Cdc48 和泛素结合蛋白赋予酵母选择性的正向蛋白分拣和进入多泡体的能力。
Cdc48 and ubiquilins confer selective anterograde protein sorting and entry into the multivesicular body in yeast.
机构信息
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
出版信息
Mol Biol Cell. 2018 Apr 15;29(8):948-963. doi: 10.1091/mbc.E17-11-0652. Epub 2018 Mar 30.
Abstract
Cdc48/p97 and the ubiquilin family of UBA-UBL proteins are known for their role in the retrotranslocation of damaged proteins from the endoplasmic reticulum. We demonstrate that Cdc48 and the ubiquilin-like proteins in yeast also play a role in the anterograde trafficking of proteins, in this case the vacuolar protease, Cps1.
摘要
Cdc48/p97 和泛素结合结构域-泛素样蛋白家族的 UBA-UBL 蛋白以其在将内质网中受损蛋白质逆行转运中的作用而闻名。我们证明酵母中的 Cdc48 和泛素样蛋白也在蛋白质的正向转运中发挥作用，在这种情况下是液泡蛋白酶 Cps1。
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