6-羟基苯并[a]芘对DNA的序列特异性修饰
Sequence-specific modification of DNA by 6-hydroxybenzo[a]pyrene.
作者信息
Morita J, Ueda K, Kobayashi S, Komano T
出版信息
Biochim Biophys Acta. 1986 Oct 16;868(1):87-90. doi: 10.1016/0167-4781(86)90090-4.
PMID:2944542
Abstract
6-Hydroxybenzo[a]pyrene cleaved phi X174 supercoiled DNA to open circular DNA in the presence of heavy metal ions. It induced an alkali-labile modification in DNA via an oxygen-radical-mediated reaction; the most frequent alkali-labile sites were on the 3' side of the pyrimidine residues of the pyrimidine cluster.
摘要
在重金属离子存在的情况下，6-羟基苯并[a]芘将φX174超螺旋DNA切割成开环DNA。它通过氧自由基介导的反应在DNA中诱导了一种碱不稳定修饰；最常见的碱不稳定位点位于嘧啶簇嘧啶残基的3'侧。
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