Akhmedov N A, Suleĭmanova E V, Ibragimov E I, Godzhaev N M
Biofizika. 1986 Jul-Aug;31(4):561-3.
Using conformational analysis spatial structure and conformational properties of the N-terminal tridecapeptide--endorphine molecules were investigated. Calculations were based on the fragmental analysis using non-valent, electrostatic, torsional interactions and hydrogen bonds. It was shown that tridecapeptide could exist in several low-energetical conformational states. Enkephaline fragments structure depends on the most perspective structure of free metioninenkephaline. The results can be used for conformational analysis of endorphine molecules, for structure--function relations study.
利用构象分析研究了N-末端十三肽 - 内啡肽分子的空间结构和构象性质。计算基于片段分析，采用非价键、静电、扭转相互作用和氢键。结果表明，十三肽可以以几种低能量构象状态存在。脑啡肽片段的结构取决于游离甲硫氨酸脑啡肽的最具前景的结构。这些结果可用于内啡肽分子的构象分析以及结构 - 功能关系的研究。
