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[海鲸生长激素促脂活性片段的三维结构]

[Three-dimensional structure of the lipotropic active fragment of sea whale somatotropin].

作者信息

Mzareulov K D

出版信息

Biokhimiia. 1990 Feb;55(2):247-55.

PMID:2340314
Abstract

Using semiempirical conformational analysis method, the spatial structure and conformational properties of the sea-whale somatotropin lipotropic action were investigated. The calculations were based on the fragmental analysis using non-valent, electrostatic interactions, torsional barriers and hydrogen bonds. The computer data suggest that this molecule can exist only in several low energy conformational states. The experimental results can be used for the analysis of structural-and-functional relationships.

摘要

采用半经验构象分析方法,对海鲸生长激素的促脂作用的空间结构和构象性质进行了研究。计算基于使用非价、静电相互作用、扭转势垒和氢键的片段分析。计算机数据表明,该分子只能以几种低能量构象状态存在。实验结果可用于分析结构与功能的关系。

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