严重皮肤不良反应的治疗方法。
Treatments for Severe Cutaneous Adverse Reactions.
机构信息
Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
出版信息
J Immunol Res. 2017;2017:1503709. doi: 10.1155/2017/1503709. Epub 2017 Dec 27.
Abstract
Severe cutaneous adverse reaction (SCAR) is life-threatening. It consists of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed drug eruptions (GBFDE). In the past years, emerging studies have provided better understandings regarding the pathogenesis of these diseases. These diseases have unique presentations and distinct pathomechanisms. Therefore, theoretically, the options of treatments might be different among various SCARs. However, due to the rarity of these diseases, sufficient evidence is still lacking to support the best choice of treatment for patients with SCAR. Herein, we will provide a concise review with an emphasis on the characteristics and treatments of each SCAR. It may serve as a guidance based on the current best of knowledge and may shed light on the directions for further investigations.
摘要
严重皮肤不良反应（SCAR）具有生命威胁。它包括史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症（SJS/TEN）、药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）、急性全身性发疹性脓疱病（AGEP）和全身性大疱固定性药疹（GBFDE）。在过去的几年中，新出现的研究为这些疾病的发病机制提供了更好的理解。这些疾病具有独特的表现和不同的发病机制。因此，理论上，各种 SCAR 的治疗选择可能不同。然而，由于这些疾病的罕见性，仍然缺乏足够的证据来支持 SCAR 患者治疗的最佳选择。在此，我们将提供一个简洁的综述，重点介绍每种 SCAR 的特征和治疗方法。它可以根据当前最佳知识提供指导，并为进一步研究指明方向。
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