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聚乙二醇包覆的钴铁氧体纳米颗粒的毒性及姜黄素的治疗效果

Toxicity of PEG-Coated CoFeO Nanoparticles with Treatment Effect of Curcumin.

作者信息

Akhtar Shahnaz, An Wenzhen, Niu Xiaoying, Li Kang, Anwar Shahzad, Maaz Khan, Maqbool Muhammad, Gao Lan

机构信息

School of Life Sciences, Lanzhou University, Lanzhou, Gansu, 730000, People's Republic of China.

Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu, 730000, China.

出版信息

Nanoscale Res Lett. 2018 Feb 14;13(1):52. doi: 10.1186/s11671-018-2468-7.

DOI:10.1186/s11671-018-2468-7
PMID:29445876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5812961/
Abstract

In this work, CoFeO nanoparticles coated with polyethylene glycol (PEG) were successfully synthesized via a hydrothermal technique. Morphological studies of the samples confirmed the formation of polycrystalline pure-phase PEG-CoFeO nanoparticles with sizes of about 24 nm. Toxicity induced by CoFeO nanoparticles was investigated, and biological assays were performed to check the toxicity effects of CoFeO nanoparticles. Moreover, the healing effect of toxicity induced in living organisms was studied using curcumin and it was found that biochemical indexes detoxified and improved to reach its normal level after curcumin administration. Thus, PEG-coated CoFeO synthesized through a hydrothermal method can be utilized in biomedical applications and curcumin, which is a natural chemical with no side effects, can be used for the treatment of toxicity induced by the nanoparticles in living organisms.

摘要

在本工作中，通过水热技术成功合成了包覆聚乙二醇（PEG）的CoFeO纳米颗粒。对样品的形态学研究证实形成了尺寸约为24nm的多晶纯相PEG-CoFeO纳米颗粒。研究了CoFeO纳米颗粒诱导的毒性，并进行了生物学试验以检查CoFeO纳米颗粒的毒性作用。此外，使用姜黄素研究了在活生物体中诱导的毒性的愈合效果，发现给药姜黄素后生化指标解毒并改善至正常水平。因此，通过水热法合成的PEG包覆的CoFeO可用于生物医学应用，而姜黄素作为一种无副作用的天然化学物质，可用于治疗纳米颗粒在活生物体中诱导的毒性。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c1c/5812961/2a609b92d8ff/11671_2018_2468_Fig10_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c1c/5812961/1d67762cca12/11671_2018_2468_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c1c/5812961/0e61c8afff18/11671_2018_2468_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c1c/5812961/2dd23321a531/11671_2018_2468_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c1c/5812961/ad7f5c334601/11671_2018_2468_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c1c/5812961/2a609b92d8ff/11671_2018_2468_Fig10_HTML.jpg

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