Department of Neurosciences, San Bortolo Hospital, Vicenza, Italy.
U.O. Neurologia, Ospedale San Bortolo, 36100, Vicenza, Italy.
Neurol Sci. 2018 May;39(5):835-839. doi: 10.1007/s10072-018-3252-2. Epub 2018 Feb 14.
Parkinson's disease (PD) is a neurodegenerative disorder which affects the quality of life of patient and their family. Sleep disorders appear in 80-90% of PD patients and have a great impact on the PD well-being. We examined the relationship of patients' sleep quality and depression on burden, mood, quality of life, and quality of sleep of their caregivers. A multicenter, regional (Veneto), observational, cross-sectional study that included 55 patient-caregiver pairs was conducted. Patients were assessed using Parkinson's Disease Sleep Scale (PDSS) and Epworth Sleepiness Scale (ESS) for sleep disorders, Beck Depression Inventory (BDI) as a measure of depression, and Parkinson's Disease Questionnaire (PDQ-39) as a measure of quality of life. Caregivers were evaluated by the Caregiver Burden Inventory (CBI) a measure of burden, BDI, SF-36 Health Survey as measures of HRQoL, and Medical Outcomes Study-Sleep Scale (MOS-SS) for quality of sleep. CBI, HRQoL, MOS-SS, and BDI scores displayed no association with patients' age, cognition (Mini Mental State Examination (MMSE) and Frontal Assessment Battery (FAB)), disease duration, and Hoehn and Yahr (H&Y), and UPDRS III scales whereas were significantly correlated with patients' quality of sleep, depression, and quality life. CBI and HRQoL were also associated respectively with patients' ESS and L-dopa daily dose. This study underscores the presence of a significant relationship between patient and caregiver quality of life. Interestingly, sleep quality and depression rather than motor disability best predicted caregivers' well-being.
帕金森病（PD）是一种神经退行性疾病，会影响患者及其家庭的生活质量。80-90%的 PD 患者存在睡眠障碍，对 PD 的幸福感有很大影响。我们研究了患者的睡眠质量与抑郁对其照顾者的负担、情绪、生活质量和睡眠质量的关系。进行了一项多中心、区域性（威尼托）、观察性、横断面研究，纳入了 55 对患者-照顾者。使用帕金森病睡眠量表（PDSS）和 Epworth 嗜睡量表（ESS）评估睡眠障碍，贝克抑郁量表（BDI）评估抑郁，帕金森病问卷（PDQ-39）评估生活质量。采用照顾者负担量表（CBI）评估负担，贝克抑郁量表（BDI）、SF-36 健康调查量表评估 HRQoL，医学结局研究睡眠量表（MOS-SS）评估睡眠质量评估照顾者。CBI、HRQoL、MOS-SS 和 BDI 评分与患者的年龄、认知（简易精神状态检查（MMSE）和额叶评估量表（FAB））、疾病持续时间和 Hoehn 和 Yahr（H&Y）和 UPDRS III 量表无显著相关性，但与患者的睡眠质量、抑郁和生活质量显著相关。CBI 和 HRQoL 还分别与患者的 ESS 和 L-多巴每日剂量相关。这项研究强调了患者和照顾者生活质量之间存在显著关系。有趣的是，睡眠质量和抑郁而不是运动障碍最能预测照顾者的幸福感。
