Virology Unit, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Department of Dermatology, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
J Med Virol. 2018 Aug;90(8):1323-1327. doi: 10.1002/jmv.25052. Epub 2018 May 10.
Hepatitis E virus (HEV) is a feco-orally transmitted pathogen and one of the most common cause of acute hepatitis worldwide. Recent studies in developed countries suggested that a direct human-to-human contact such as for sexually transmitted diseases may play a significant role in the HEV spread. The aim of this study was to investigate the seroprevalence of HEV and HAV in a group of MSM, including subjects HIV, and Treponema infected, in Milan, Italy. The overall anti HEV IgG seroprevalence in MSM was 10.2% (65/636), instead in the control group the detection rate was 5.2% (15/288) (P < 0.05); the anti HAV seroprevalence was 42.8% in MSM, when in the control group the positivity rate was 29.2% (P < 0.05). The rate of coinfection HEV/HAV was 14.6% in MSM and 1% in control group (P < 0.05). In the future, sexual history, HIV status, and STI risk might address specific investigations to prevent spread of pathogens such HEV in MSM, before becoming a substantial public health problem like for HAV outbreaks.
戊型肝炎病毒（HEV）是一种经粪-口途径传播的病原体，也是全球范围内急性肝炎的最常见病因之一。最近在发达国家的研究表明，直接的人与人之间的接触，如性传播疾病，可能在 HEV 的传播中发挥重要作用。本研究旨在调查意大利米兰一组男男性行为者（MSM）中 HEV 和 HAV 的血清流行率，包括 HIV 和梅毒感染者。MSM 中抗 HEV IgG 的总血清流行率为 10.2%（65/636），而对照组的检出率为 5.2%（15/288）（P<0.05）；MSM 中抗 HAV 的血清流行率为 42.8%，而对照组的阳性率为 29.2%（P<0.05）。MSM 中 HEV/HAV 的合并感染率为 14.6%，而对照组为 1%（P<0.05）。在未来，性行为史、HIV 状况和性传播感染风险可能会针对特定人群进行具体调查，以防止 HEV 等病原体在 MSM 中的传播，避免其像 HAV 爆发那样成为严重的公共卫生问题。
