儿童心房利钠肽与容量变化

Atrial natriuretic peptide and volume changes in children.

作者信息

Tulassay T, Rascher W, Ganten D, Schärer K, Lang R E

出版信息

Clin Exp Hypertens A. 1986;8(4-5):695-701. doi: 10.3109/10641968609046587.

DOI:10.3109/10641968609046587

Abstract

The effect of volume changes on the plasma concentration of atrial natriuretic peptide (ANP) was investigated. In children with chronic renal failure predialysis plasma ANP was higher as compared to normal children and decreased significantly during hemodialysis. The decrease in plasma ANP correlated with body weight reduction. On the other hand, increase in plasma volume by infusion of albumin in children with nephrotic syndrome caused significant rise in plasma ANP and an increased natriuresis. Our data demonstrate that an expanded extracellular fluid volume and/or plasma volume appears to be a major stimulus for the release in ANP in children.

摘要

研究了容量变化对心房利钠肽（ANP）血浆浓度的影响。与正常儿童相比，慢性肾衰竭儿童透析前血浆ANP较高，且在血液透析期间显著降低。血浆ANP的降低与体重减轻相关。另一方面，在肾病综合征患儿中输注白蛋白使血浆容量增加，导致血浆ANP显著升高及尿钠排泄增加。我们的数据表明，细胞外液容量和/或血浆容量的增加似乎是儿童ANP释放的主要刺激因素。