压力感受器反射在麻醉犬对合成人心房利钠肽的血压及交感神经反应中的作用。

Participation of baroreceptor reflexes in blood pressure and sympathetic nerve responses to a synthetic human atrial natriuretic peptide in anesthetized dogs.

作者信息

Koyama S, Nishida Y, Hosomi H, Abe Y

出版信息

Eur J Pharmacol. 1986 Aug 7;127(1-2):43-8. doi: 10.1016/0014-2999(86)90204-9.

Abstract

The effects of a synthetic alpha human atrial natriuretic polypeptide (hANP) on systemic blood pressure and renal nerve activity were studied before and after sinoaortic denervation with vagotomy in anesthetized dogs. Intravenous injection of hANP (1 microgram/kg) in animals with the neuraxis intact produced a mild decrease in systemic blood pressure and a significant increase in renal sympathetic nerve activity. However, in animals with sinoaortic denervation and vagotomy, a profound fall in blood pressure occurred after administration of hANP. Renal nerve activity in these animals was reduced significantly, in parallel with decreases in systemic blood pressure. These results indicate that activation of peripheral baroreceptors minimizes the hypotension induced by intravenous injection of hANP, and may mask at least centrally mediated cardiovascular effects of hANP.

摘要

在麻醉犬中，研究了合成的α-人心房利钠多肽（hANP）在去窦主动脉神经加迷走神经切断术前、后的情况下对全身血压和肾神经活动的影响。完整神经轴的动物静脉注射hANP（1微克/千克）可使全身血压轻度降低，肾交感神经活动显著增加。然而，在去窦主动脉神经加迷走神经切断的动物中，注射hANP后血压大幅下降。这些动物的肾神经活动与全身血压下降同步显著降低。这些结果表明，外周压力感受器的激活可使静脉注射hANP诱导的低血压最小化，并可能掩盖至少hANP的中枢介导的心血管效应。