Suzuki S, Takeshita A, Imaizumi T, Hirooka Y, Yoshida M, Nakamura M
Research Institute of Angiocardiology, Kyushu University, Faculty of Medicine, Fukuoka, Japan.
Clin Exp Hypertens A. 1988;10 Suppl 1:263-8. doi: 10.3109/10641968809075978.
This study aimed to examine whether atrial natriuretic peptide (ANP) alters arterial baroreceptor control of sympathetic nerve activity (SNA) by acting on the central nervous system (CNS). In rabbits anesthetized with alpha-chloralose, we examined changes in arterial pressure and renal SNA in response to graded electrical stimulation (1.7, 3.3, 5.0 Hz) of aortic depressor nerves during the intravenous (IV) infusion of saline or alpha-human atrial natriuretic peptide (alpha-hANP) (0.1, 1.0 microgram/kg/min) or after the intracerebroventricular (ICV) injections of saline or alpha-hANP (3, 10 micrograms). Sinoaortic denervation and bilateral vagotomy were done before examination in all rabbits to eliminate the influence of the known effects of ANP on arterial and cardiac receptors. IV alpha-hANP decreased arterial pressure but did not alter renal SNA. ICV alpha-hANP did not change arterial pressure or renal SNA. Arterial pressure and renal nerve responses to graded electrical stimulation of aortic depressor nerves were not altered by IV or ICV alpha-hANP. These results suggest that alpha-hANP does not modulate control of renal SNA by acting on CNS.
本研究旨在探讨心房利钠肽（ANP）是否通过作用于中枢神经系统（CNS）来改变动脉压力感受器对交感神经活动（SNA）的控制。在使用α-氯醛糖麻醉的兔子中，我们在静脉内（IV）输注生理盐水或α-人心房利钠肽（α-hANP）（0.1、1.0微克/千克/分钟）期间，或在脑室内（ICV）注射生理盐水或α-hANP（3、10微克）后，检查了主动脉减压神经分级电刺激（1.7、3.3、5.0赫兹）引起的动脉血压和肾交感神经活动的变化。在所有兔子检查前进行了窦主动脉去神经支配和双侧迷走神经切断术，以消除ANP对动脉和心脏感受器已知作用的影响。静脉注射α-hANP可降低动脉血压，但不改变肾交感神经活动。脑室内注射α-hANP不改变动脉血压或肾交感神经活动。静脉注射或脑室内注射α-hANP均未改变动脉血压和肾神经对主动脉减压神经分级电刺激的反应。这些结果表明，α-hANP不会通过作用于中枢神经系统来调节对肾交感神经活动的控制。
