Kollin E, Fehér T
Exp Clin Endocrinol. 1986 Jul;87(2):211-4. doi: 10.1055/s-0029-1210546.
Greater than normal bone mineral content, bone width of the radius measured by photon absorptiometry and bone mineral content to bone width ratio found in women with hyperostosis frontalis interna pointed on a generalized alteration of the skeletal system. An increase in serum dehydroepiandosterone, its sulphate and testosterone levels and a significant correlation between serum free dehydroepiandosterone and bone mineral content in subjects without any sign of hirsutism or obesity suggested an involvement of androgens in pathogenesis of this metabolic bone disorder.
通过光子吸收法测量发现，额骨内板增生女性的桡骨骨矿物质含量高于正常水平，骨宽度以及骨矿物质含量与骨宽度之比，表明骨骼系统存在全身性改变。在没有多毛症或肥胖迹象的受试者中，血清脱氢表雄酮、其硫酸盐和睾酮水平升高，且血清游离脱氢表雄酮与骨矿物质含量之间存在显著相关性，提示雄激素参与了这种代谢性骨病的发病机制。
