Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
Fitoterapia. 2018 Jun;127:123-128. doi: 10.1016/j.fitote.2018.02.017. Epub 2018 Feb 12.
Five new megastigmane glycosides, urenalobasides A-E (1-5), together with 11 known ones (6-16) were isolated from Urena lobata. Their structures were determined by extensive spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism method. Compounds 1 and 2 are two unusual megastigmanes structurally containing a 6/5 fused ring system. Compound 3 exhibits inhibition of nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells with IC value of 53.7 ± 1.0 μM (positive control, dexamethasone, IC = 16.6 ± 0.8 μM).
从三裂叶蟛蜞菊中分离得到了五个新的羽扇豆烷糖苷，尿烷苷 A-E（1-5），以及 11 个已知的化合物（6-16）。通过广泛的光谱和光谱数据（1D 和 2D NMR、IR 和 HRESIMS）以及计算电子圆二色性方法确定了它们的结构。化合物 1 和 2 是两个结构上含有 6/5 稠合环系的不寻常羽扇豆烷。化合物 3 对 LPS 刺激的 RAW264.7 巨噬细胞细胞中一氧化氮（NO）的产生具有抑制作用，IC 值为 53.7±1.0 μM（阳性对照，地塞米松，IC=16.6±0.8 μM）。
