Université catholique de Louvain, Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Brussels, Belgium.
Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Brussels, Belgium.
Adv Drug Deliv Rev. 2018 Apr;129:262-284. doi: 10.1016/j.addr.2018.02.001. Epub 2018 Feb 12.
Oxygen plays a key role in wound healing, and hypoxia is a major cause of wound healing impairment; therefore, treatments to improve hemodynamics and increase wound oxygenation are of particular interest for the treatment of chronic wounds. This article describes the roles of oxygen and angiogenesis in wound healing as well as the tools used to evaluate tissue oxygenation and perfusion and then presents a review of nanomedicines and gene therapies designed to improve perfusion and oxygenation and accelerate wound healing.
氧气在伤口愈合中起着关键作用，而缺氧是伤口愈合受损的主要原因；因此，改善血液动力学和增加伤口氧合的治疗方法对于治疗慢性伤口特别有意义。本文描述了氧气和血管生成在伤口愈合中的作用以及用于评估组织氧合和灌注的工具，然后回顾了旨在改善灌注和氧合并加速伤口愈合的纳米药物和基因治疗。
