Zhang Yuxiang, Yu Yuanyuan, Yu Lien, Wang Fang, Yang Fuwei, Liang Shiyu, Xu Wen, Ji Mengying, Geng Yinuo, Xue Jingwei, Han Chunmao, Zhang Zhongtao, Zhang Yilin
Department of Burns and Wound Care Center, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Tumor Precise Intervention and Translational Medicine Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China.
Front Pharmacol. 2025 Jun 4;16:1580994. doi: 10.3389/fphar.2025.1580994. eCollection 2025.
Bacterial infection, excessive inflammation, and delayed re-epithelialization are the biggest obstacles to diabetic wound healing and burn injuries. As a classic prescription, BaDuShengJi San (BDS) has been proven to accelerate chronic wound healing through anti-bacterial and anti-inflammatory mechanisms. However, there are few reports on its role in preventing the malignant progression of deep burns or accelerating deep burn wound healing. Furthermore, the powder formulation of BDS has limited application scenarios, difficult dosage control, potential environmental pollution, and contradiction with the theory of moist wound healing, which has constrained its scope of application and efficacy to some extent. To address these issues, this study developed a novel hydrogel formulation incorporating BDS using carbomer 940 as the gel matrix, glycerol as a humectant, and triethanolamine as a pH adjuster, through orthogonal design. The results demonstrated that the prepared BDS-loaded gel (BDN) exhibited excellent stability and good biocompatibility, preserving the antibacterial and angiogenesis-promoting properties of BDS while enhancing its anti-inflammatory capabilities. Additionally, BDN significantly accelerated re-epithelialization in diabetic chronic wounds and burn wounds compared to BDS, achieving superior healing quality and mitigating renal damage associated with long-term BDS application. This study provides a comprehensive strategy for accelerating wound healing in diabetic chronic wounds and deep burn injuries and offers insights into expanding the clinical application of BDS and enhancing its therapeutic effects.
细菌感染、过度炎症反应和上皮再形成延迟是糖尿病伤口愈合和烧伤的最大障碍。作为一种经典方剂，拔毒生肌散（BDS）已被证明可通过抗菌和抗炎机制加速慢性伤口愈合。然而，关于其在预防深度烧伤恶性进展或加速深度烧伤伤口愈合方面的作用报道较少。此外，BDS的散剂剂型应用场景有限、剂量控制困难、存在潜在环境污染且与湿性伤口愈合理论相悖，在一定程度上限制了其应用范围和疗效。为解决这些问题，本研究通过正交设计，以卡波姆940为凝胶基质、甘油为保湿剂、三乙醇胺为pH调节剂，研制了一种新型的含BDS水凝胶制剂。结果表明，所制备的载BDS凝胶（BDN）具有优异的稳定性和良好的生物相容性，在保留BDS抗菌和促血管生成特性的同时增强了其抗炎能力。此外，与BDS相比，BDN显著加速了糖尿病慢性伤口和烧伤伤口的上皮再形成，实现了更优的愈合质量，并减轻了长期应用BDS相关的肾损伤。本研究为加速糖尿病慢性伤口和深度烧伤损伤的伤口愈合提供了一种综合策略，并为拓展BDS的临床应用和增强其治疗效果提供了见解。
