Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania.
Pain Center, Department of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
Pharmacology. 2018;101(5-6):262-268. doi: 10.1159/000486865. Epub 2018 Feb 15.
The functioning of microglial cells inside the central nervous system depends on their ion channels expression. Microglia are capable of synthesizing different cytokines and chemokines, including CXCL1, and responding to their action via specific receptors. In this study, we explore the effect of intrathecal injection of CXCL1 on potassium currents, expressed in CX3CR1-Green Fluorescent Protein labeled microglia in transgenic mice. The results showed that CXCL1 hyperpolarized the cells by enhancing inward rectifying potassium currents and increasing the membrane area, suggesting an activating effect on microglia.
中枢神经系统内小胶质细胞的功能取决于其离子通道的表达。小胶质细胞能够合成不同的细胞因子和趋化因子，包括 CXCL1，并通过特定的受体对其作用做出反应。在这项研究中，我们探索了鞘内注射 CXCL1 对 CX3CR1-Green Fluorescent Protein 标记的转基因小鼠小胶质细胞中钾电流的影响。结果表明，CXCL1 通过增强内向整流钾电流和增加细胞膜面积使细胞超极化，提示对小胶质细胞有激活作用。
