Kim Ji-Hyun, Park Sang-Won, Lim Hyun-Pil, Park Chan, Yun Kwi-Dug
Department of Prosthodontics, Dental Science Reaearch Institute, School of Dentistry, Chonnam National University, Gwangju, 61186, Republic of Korea.
J Nanosci Nanotechnol. 2018 Feb 1;18(2):1237-1240. doi: 10.1166/jnn.2018.14873.
The major failure of dental restorations is caused by dental caries by S. mutans. This study evaluated the effect of nanosized silver ions in feldspathic porcelain on cytotoxicity and antimicrobial activity. The control group was feldspathic porcelain (Noritake EX-3, Kuraray Noritake Dental Inc., Japan) that did not contain Ag (silver). The experimental groups were feldspathic porcelain mixed with colloidal solutions of nanosized silver ions in mixtures of 5% 10%, 20%, 30%. Cell activity assays evaluated with osteoblast hFOB 1.19 cells (human Fetal Osteoblastic cell line, ATCC® CRL- 11372™) and antimicrobial activity test used the streptococcus mutans (S. mutans). According to the observations, the addition of Ag to feldspathic porcelain led to increased cell activity and showed excellent antibacterial performance. Especially, the feldspathic porcelain with 30% nanosized Ag ion appeared to have a significant antimicrobial effect, this allows for the possibility of various clinical applications for such material, including use in dental prosthesis and implants.
牙科修复体的主要失败原因是变形链球菌导致的龋齿。本研究评估了长石质瓷中纳米银离子对细胞毒性和抗菌活性的影响。对照组为不含银（Ag）的长石质瓷（日本可乐丽诺瑞特牙科公司的Noritake EX - 3）。实验组为分别混合了5%、10%、20%、30%纳米银离子胶体溶液的长石质瓷。使用成骨细胞hFOB 1.19细胞（人胎儿成骨细胞系，ATCC® CRL - 11372™）进行细胞活性测定，并用变形链球菌（S. mutans）进行抗菌活性测试。根据观察结果，向长石质瓷中添加银会导致细胞活性增加，并显示出优异的抗菌性能。特别是，含有30%纳米银离子的长石质瓷似乎具有显著的抗菌效果，这使得这种材料在包括牙科假体和植入物在内的各种临床应用中成为可能。
