Silverman S H, Johnson M, Burdon D W, Keighley M R
J Antimicrob Chemother. 1986 Jul;18(1):107-12. doi: 10.1093/jac/18.1.107.
The pharmacokinetics of single dose intravenous ciprofloxacin in patients undergoing gastrointestinal surgery (100 mg, n = 8; 200 mg n = 18) have been studied. Following 100 mg therapeutic serum levels were maintained for approximately 40 min only and tissue concentrations were frequently less than 0.15 mg/kg. 200 mg maintained therapeutic serum levels for at least 150 min and produced mean concentrations in fat, muscle, peritoneum and gut wall of 1.04, 1.94, 1.59, and 3.39 mg/kg respectively. 200 mg iv ciprofloxacin would appear to provide adequate serum and tissue concentrations for at least 150 min.
已对接受胃肠道手术患者单剂量静脉注射环丙沙星（100毫克，n = 8；200毫克，n = 18）的药代动力学进行了研究。注射100毫克后，治疗性血清水平仅维持约40分钟，组织浓度通常低于0.15毫克/千克。200毫克可使治疗性血清水平维持至少150分钟，在脂肪、肌肉、腹膜和肠壁中的平均浓度分别为1.04、1.94、1.59和3.39毫克/千克。静脉注射200毫克环丙沙星似乎能在至少150分钟内提供足够的血清和组织浓度。
