环丙沙星浓度及结肠微生物群对结直肠手术患者的影响。
Ciprofloxacin concentrations and impact of the colon microflora in patients undergoing colorectal surgery.
作者信息
Brismar B, Edlund C, Malmborg A S, Nord C E
机构信息
Department of Surgery, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
出版信息
Antimicrob Agents Chemother. 1990 Mar;34(3):481-3. doi: 10.1128/AAC.34.3.481.
Abstract
Ciprofloxacin was given perorally in two doses of 750 mg each with a 12-h interval starting 24 h prior to surgery, 400 mg of ciprofloxacin was given intravenously at the induction of anesthesia, and 400 mg of ciprofloxacin was given 12 h later to 21 patients undergoing elective colorectal surgery. The maximum concentrations in serum (mean value +/- standard deviation, 11.1 +/- 7.8 mg/liter) during surgery were reached 30 min after ciprofloxacin was administered. The ciprofloxacin concentrations in the intestinal mucosa samples were 2.7 to 37.8 mg/kg of tissue weight, and the concentrations in the fecal samples were less than 0.1 to 858 mg/kg. The aerobic and anaerobic bacteria in the fecal flora were suppressed markedly during the prophylaxis period. No postoperative infections occurred.
摘要
环丙沙星在手术前24小时开始口服，分两次给药，每次750毫克，间隔12小时。在麻醉诱导时静脉注射400毫克环丙沙星，12小时后对21例行择期结直肠手术的患者再静脉注射400毫克环丙沙星。环丙沙星给药后30分钟达到手术期间血清中的最高浓度（平均值±标准差，11.1±7.8毫克/升）。肠黏膜样本中环丙沙星浓度为2.7至37.8毫克/千克组织重量，粪便样本中的浓度为小于0.1至858毫克/千克。在预防期间，粪便菌群中的需氧菌和厌氧菌受到明显抑制。未发生术后感染。
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