采用新型仿生方案恢复成人阻塞性睡眠呼吸暂停患者的睡眠：临床病例报告

Restoration of sleep using a novel biomimetic protocol for adult OSA: Clinical case report.

作者信息

Singh G Dave, Kraver Mark, Chernyshev Oleg

机构信息

a Vivos BioTechnologies, Inc. , Cedar Crest , NM , USA.

b Cape Dental Care , Cape Coral , FL , USA.

出版信息

Cranio. 2019 Mar;37(2):136-139. doi: 10.1080/08869634.2018.1425235. Epub 2018 Feb 15.

DOI:10.1080/08869634.2018.1425235

PMID:29448905

Abstract

BACKGROUND

A sleep study of a 56-year old male with excessive daytime sleepiness demonstrated an AHI of 16.4hr with 13% of total sleep time in REM sleep and a mean oxygen desaturation (SpO) of 86%.

CLINICAL PRESENTATION

On intra-oral examination, it was found that the patient had maxillary hypoplasia and bilateral torus mandibularis. A 3D cone-beam CT (CBCT) scan was taken, and 28 craniofacial parameters were measured. Surgical reduction of the mandibular tori followed by biomimetic oral appliance therapy (BOAT) was initiated. After 14 months, a post-treatment CBCT scan revealed that 70% of parameters measured had improved. Therefore, another sleep study was performed with no device in the mouth. This follow-up home sleep test demonstrated that the AHI fell to 5.3hrhr; with 27% REM sleep, and a mean SpO of 93% without any device in the mouth.

CONCLUSION

These findings suggest that BOAT might be able to restore sleep in certain adult cases.

摘要

背景

对一名56岁白天过度嗜睡男性进行的睡眠研究显示，其呼吸暂停低通气指数（AHI）为每小时16.4次，快速眼动（REM）睡眠占总睡眠时间的13%，平均氧饱和度（SpO）为86%。

临床表现

口腔检查发现该患者上颌发育不全且双侧下颌隆突。进行了三维锥形束CT（CBCT）扫描，并测量了28项颅面参数。首先进行下颌隆突手术复位，然后采用仿生口腔矫治器疗法（BOAT）。14个月后，治疗后的CBCT扫描显示，所测量的参数中有70%得到改善。因此，在未佩戴任何装置的情况下进行了另一项睡眠研究。这项后续的家庭睡眠测试表明，AHI降至每小时5.3次；快速眼动睡眠占27%，且在未佩戴任何装置的情况下平均SpO为93%。