Karlinsky H
J Am Geriatr Soc. 1986 Oct;34(10):728-34. doi: 10.1111/j.1532-5415.1986.tb04304.x.
Alzheimer's disease is a progressive dementing illness accompanied by characteristic neuropathologic changes. Although its etiology is unknown, its risk of occurrence increases with age and in relatives of affected individuals. An additional risk factor is the presence of Down's syndrome. Almost all individuals with Down's syndrome over the age of 40 have the characteristic neuropathologic changes of Alzheimer's disease at autopsy. Although clinical evidence for Alzheimer's disease in Down's syndrome is less consistent, the association between Alzheimer's disease and Down's syndrome may contribute to an understanding of Alzheimer's disease in the general population. This article summarizes the neuropathologic and clinical observations of Alzheimer's disease in Down's syndrome and reviews the hypotheses that attempt to account for this association.
阿尔茨海默病是一种伴有特征性神经病理改变的进行性痴呆症。尽管其病因不明，但其发病风险随年龄增长以及在受影响个体的亲属中增加。另一个风险因素是唐氏综合征的存在。几乎所有40岁以上的唐氏综合征患者在尸检时都有阿尔茨海默病的特征性神经病理改变。尽管唐氏综合征患者中阿尔茨海默病的临床证据不太一致，但阿尔茨海默病与唐氏综合征之间的关联可能有助于理解一般人群中的阿尔茨海默病。本文总结了唐氏综合征中阿尔茨海默病的神经病理和临床观察结果，并综述了试图解释这种关联的假说。
