Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA, United States.
Front Immunol. 2018 Feb 1;9:159. doi: 10.3389/fimmu.2018.00159. eCollection 2018.
The production of high-affinity and broadly neutralizing antibodies plays a key role in the defense against pathogens. These antibody responses require effective germinal center (GC) reaction within anatomical niches of GCs, where follicular helper T (Tfh) cells provide cognate help to B cells for T cell-dependent antibody responses. Emerging evidences indicate that GC reaction in normal state and perhaps establishment of latent Tfh cell reservoir in HIV/SIV infection are tightly regulated by epigenetic histone modifications, which are responsible for activating or silencing chromatin. A better understanding of the mechanisms behind GC responses at cellular and molecular levels thus provides necessary knowledge for vaccination and immunotherapy. In this review, we discussed the epigenetic regulation of GC responses, especially for GC B and Tfh cell under normal state or HIV/SIV infection.
高亲和力和广泛中和抗体的产生在抵御病原体方面起着关键作用。这些抗体反应需要在生发中心（GC）的解剖龛内进行有效的生发中心（GC）反应，其中滤泡辅助 T（Tfh）细胞为 B 细胞提供同源帮助，以进行 T 细胞依赖性抗体反应。新出现的证据表明，正常状态下的 GC 反应，也许是 HIV/SIV 感染中潜伏的 Tfh 细胞库的建立，都受到表观遗传组蛋白修饰的严格调控，这些修饰负责激活或沉默染色质。因此，更好地理解细胞和分子水平上 GC 反应的机制为疫苗接种和免疫治疗提供了必要的知识。在这篇综述中，我们讨论了 GC 反应的表观遗传调控，特别是在正常状态或 HIV/SIV 感染下的 GC B 和 Tfh 细胞。
