Khan Shahida, Ali Ashraf, Khan Sarah, Bakillah Ahmed, Damanhouri Ghazi, Khan Aziz, Makki Ahmad, AlAnsari Ibtehal, Banu Naheed
1Applied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz University, P.O.Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.
2National Brain Research Center, Manesar, Gurgaon, 122051 India.
Nutr Metab (Lond). 2018 Feb 9;15:13. doi: 10.1186/s12986-018-0251-5. eCollection 2018.
Liver dysfunction is a topic of global concern with many advancing therapies being researched. Though vitamin D takes a center place, other therapies especially nutritional are also gaining ground. Vitamin D has gone beyond its role in skeletal disorders by showcasing its associations in other metabolic dysfunctions too.
Epidemiological evidences show a correlation between the status of vitamin D and different forms of cancer. Vitamin D receptors and alterations in gene expression appear decisive in the development of chronic liver disorders. Nutritional status therefore plays a significant role in avoiding the complications related to liver dysfunctions, making it mandatory in maintaining vitamin D sufficiency in the body. Therapies with omega-3 fatty acids, antioxidants, amino acids, steroids also render benefits which could be further explored. Recent research on the progression of certain forms of liver cancer using vitamin D analogs like Seocalcitol EB 1089 has shown good promise.
The anti-inflammatory and immuno- regulatory properties of vitamin D makes its analogs, suitable candidates of better choice for the prevention and treatment of liver disorders and cancer.
肝功能障碍是一个全球关注的话题，目前正在研究多种先进疗法。尽管维生素D占据核心地位，但其他疗法尤其是营养疗法也在逐渐兴起。维生素D通过展示其在其他代谢功能障碍中的关联，已超越其在骨骼疾病中的作用。
流行病学证据表明维生素D状态与不同形式的癌症之间存在关联。维生素D受体和基因表达的改变在慢性肝脏疾病的发展中似乎起决定性作用。因此，营养状况在避免与肝功能障碍相关的并发症方面起着重要作用，这使得维持体内维生素D充足成为必要。使用ω-3脂肪酸、抗氧化剂、氨基酸、类固醇进行治疗也有好处，有待进一步探索。最近使用维生素D类似物如司骨化醇EB 1089对某些形式的肝癌进展进行的研究显示出良好前景。
维生素D的抗炎和免疫调节特性使其类似物成为预防和治疗肝脏疾病及癌症的更优选择。
