Ikenaga Hiroki, Kurisu Satoshi, Watanabe Noriaki, Shimonaga Takashi, Higaki Tadanao, Iwasaki Toshitaka, Utsunomiya Hiroto, Mitsuba Naoya, Ishibashi Ken, Dohi Yoshihiro, Fukuda Yukihiro, Imai Katsuhiko, Sueda Taijiro, Kihara Yasuki
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Department of Cardiovascular Surgery, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Int J Cardiol Heart Vessel. 2014 Aug 15;4:30-34. doi: 10.1016/j.ijchv.2014.08.002. eCollection 2014 Sep.
Both aortic aneurysms and coronary artery ectasia (CAE) frequently coexist and are associated with more pronounced inflammation. Neutrophil to lymphocyte ratio (NL ratio) is widely used as a marker of inflammation. However, relation between CAE and NL ratio in patients with aortic aneurysms is not fully understood. This study was undertaken to assess relation between CAE and NL ratio in patients with aortic aneurysms.
This study consisted of 93 consecutive patients with aortic aneurysms (AA group) and 79 patients without aortic aneurysms who had angiographically normal coronary arteries as the control group. Moreover, patients with aortic aneurysms were classified into two groups based on the presence of CAE; CAE (+) group (n = 44) and CAE (-) group (n = 49). We compared blood chemical parameters in both groups.
In the AA group, 44 patients (47.3%) had CAE. The AA group had a significantly higher NL ratio than the control group (2.93 ± 1.43 vs. 2.45 ± 1.05, p = 0.027). Furthermore, the CAE (+) group had a significantly higher NL ratio than the CAE (-) group (3.39 ± 1.67 vs. 2.52 ± 1.04, p < 0.01). Multivariate logistic regression analysis revealed that the high NL ratio was an independent predictor for CAE in patients with aortic aneurysms (odds ratio 1.76, 95% confidence interval 1.24-2.69, p = 0.001).
Patients with aortic aneurysms had a significantly higher NL ratio than those without aortic aneurysms. Furthermore, the NL ratio might predict the presence of CAE in patients with aortic aneurysms.
主动脉瘤和冠状动脉扩张（CAE）常同时存在，且与更明显的炎症相关。中性粒细胞与淋巴细胞比值（NL比值）被广泛用作炎症标志物。然而，主动脉瘤患者中CAE与NL比值之间的关系尚未完全明确。本研究旨在评估主动脉瘤患者中CAE与NL比值之间的关系。
本研究纳入93例连续的主动脉瘤患者（AA组）和79例冠状动脉造影正常且无主动脉瘤的患者作为对照组。此外，根据是否存在CAE将主动脉瘤患者分为两组；CAE（+）组（n = 44）和CAE（-）组（n = 49）。我们比较了两组的血液化学参数。
在AA组中，44例患者（47.3%）有CAE。AA组的NL比值显著高于对照组（2.93±1.43 vs. 2.45±1.05，p = 0.027）。此外，CAE（+）组的NL比值显著高于CAE（-）组（3.39±1.67 vs. 2.52±1.04，p < 0.01）。多因素逻辑回归分析显示，高NL比值是主动脉瘤患者CAE的独立预测因素（比值比1.76，95%置信区间1.24 - 2.69，p = 0.001）。
主动脉瘤患者的NL比值显著高于无主动脉瘤患者。此外，NL比值可能预测主动脉瘤患者中CAE的存在。
