Leuven J A, van Stiphout W A, van Gelderen H H, Reeser H M, Havekes L, Hofman A
Metabolism. 1986 Oct;35(10):978-80. doi: 10.1016/0026-0495(86)90065-x.
Seventeen constitutionally tall prepubertal girls, aged 10 to 14 years, were treated with large doses of ethinyl estradiol (EE) to reduce their final height. The serum concentration of cholesterol, triglyceride, and apolipoproteins before and after four to 17 months of treatment were compared with the same variables in a reference group, initially matched for bone age and height. In the patients, cholesterol rose by 24% (1.1 +/- 0.8 mmol/L), triglyceride by 105% (0.97 +/- 0.70 mmol/L), LDL apo B by 48% (27 +/- 19 mg/dL), apo A-I by 45% (62 +/- 17 mg/dL), and apo A-II by 21% (12 +/- 11 mg/dL). In the reference group, none of these variables changed significantly. The ratio of LDL apo B/apo A-I remained constant in both groups.
17名年龄在10至14岁、体质性身材高大的青春期前女孩接受了大剂量炔雌醇（EE）治疗，以降低她们的最终身高。将治疗4至17个月前后的胆固醇、甘油三酯和载脂蛋白血清浓度与最初在骨龄和身高方面相匹配的参照组中的相同变量进行比较。在这些患者中，胆固醇升高了24%（1.1±0.8毫摩尔/升），甘油三酯升高了105%（0.97±0.70毫摩尔/升），低密度脂蛋白载脂蛋白B升高了48%（27±19毫克/分升），载脂蛋白A-I升高了45%（62±17毫克/分升），载脂蛋白A-II升高了21%（12±11毫克/分升）。在参照组中，这些变量均无显著变化。两组中低密度脂蛋白载脂蛋白B/载脂蛋白A-I的比值保持不变。
