Joss E E, Zeuner J, Zurbrügg R P, Mullis P E
Universitäts-Kinderklinik, Bern, Switzerland.
Eur J Pediatr. 1994 Nov;153(11):797-801. doi: 10.1007/BF01972886.
Fifty-two tall girls were treated for constitutionally tall stature with different ethinyl oestradiol (EE) dosages. They were divided into three different treatment groups: group B (100 micrograms EE/day; n = 11); group C (300 micrograms; n = 25) and group D (500 micrograms; n = 16) and compared with an untreated group A (n = 21) matched for age, height, bone age (BA) and height prediction. Using the height prediction method TW II, EE treatment reduced final height compared with the untreated girls in a weak dose-dependent manner, 2.3 cm (100 micrograms/day), 3.0 cm (300 micrograms/day), and 3.8 cm (500 micrograms/day). Such a dose dependency was not found on applying the Bayley-Pineau height prediction method (100 micrograms/day; 4.1 cm; 300 micrograms/day: 4.2 cm; 500 micrograms/day: 4.5 cm). However, there was a striking inverse correlation of the BA at the onset of treatment with the height reduction achieved using the TW II method (r: -0.43; P < 0.001). Importantly, girls with a BA below 12 years at the onset of treatment experienced a height reduction of more than 6 cm. CONCLUSION The EE dose used in the range of 100-500 micrograms/day is not crucial for the amount of height reduction in tall girls. In general high dose EE treatment should be given restrictively, and especially so in girls with a BA (TW2 RUS-ZH) above 12.0 years.
52名身材高挑的女孩因体质性身材高大接受了不同剂量炔雌醇（EE）的治疗。她们被分为三个不同的治疗组：B组（100微克EE/天；n = 11）；C组（300微克；n = 25）和D组（500微克；n = 16），并与年龄、身高、骨龄（BA）和身高预测相匹配的未治疗A组（n = 21）进行比较。使用TW II身高预测方法，与未治疗的女孩相比，EE治疗以弱剂量依赖性方式降低了最终身高，分别降低2.3厘米（100微克/天）、3.0厘米（300微克/天）和3.8厘米（500微克/天）。应用贝利 - 皮诺身高预测方法时未发现这种剂量依赖性（100微克/天：4.1厘米；300微克/天：4.2厘米；500微克/天：4.5厘米）。然而，治疗开始时的骨龄与使用TW II方法实现的身高降低之间存在显著的负相关（r：-0.43；P < 0.001）。重要的是，治疗开始时骨龄低于12岁的女孩身高降低超过6厘米。结论 100 - 500微克/天范围内使用的EE剂量对身材高大女孩的身高降低量并非至关重要。一般而言，高剂量EE治疗应严格限制使用，尤其是对于骨龄（TW2 RUS - ZH）超过12.0岁的女孩。
