a Department of Chemistry, Physical and Theoretical Chemistry Laboratory , University of Oxford , Oxford , UK.
Nanotoxicology. 2018 May;12(4):305-311. doi: 10.1080/17435390.2018.1438680. Epub 2018 Feb 16.
The physicochemical properties of silver nanoparticles (AgNPs) in human whole saliva are investigated herein. In authentic saliva samples, AgNPs exhibit a great stability with over 70% of the nanomaterial remaining intact after a 24-h incubation in the presence of ∼0.3 mM dissolved oxygen. The small loss of AgNPs from the saliva sample has been demonstrated to be a result of two processes: agglomeration/aggregation (not involving oxygen) and oxidative dissolution of AgNPs (assisted by oxygen). In authentic saliva, AgNPs are also shown to be more inert both chemically (silver oxidative dissolution) and electrochemically (electron transfer at an electrode) than in synthetic saliva or aqueous electrolytes. The results thus predict based on the chemical persistence (over a 24-h study) of AgNPs in saliva and hence the minimal release of hazardous Ag and reactive oxygen species that the AgNPs are less likely to cause serious harm to the oral cavity but this persistence may enable their transport to other environments.
本文研究了人全唾液中银纳米颗粒（AgNPs）的物理化学性质。在真实的唾液样本中，AgNPs 在存在约 0.3mM 溶解氧的情况下孵育 24 小时后仍保持 70%以上的纳米材料完整，具有很好的稳定性。AgNPs 从唾液样本中的少量损失已被证明是两个过程的结果：团聚/聚集（不涉及氧气）和 AgNPs 的氧化溶解（氧气辅助）。在真实的唾液中，AgNPs 在化学上（银氧化溶解）和电化学上（电极上的电子转移）比在合成唾液或电解质水溶液中更惰性。因此，根据 AgNPs 在唾液中 24 小时的化学稳定性（研究）以及危险的 Ag 和活性氧物质的最小释放，预测 AgNPs 不太可能对口腔造成严重伤害，但这种稳定性可能使其能够转移到其他环境中。
