William Harvey Research Institute, Queen Mary University of London, London, UK.
J Leukoc Biol. 2018 Aug;104(2):285-293. doi: 10.1002/JLB.1MR1117-472R. Epub 2018 Feb 16.
Dynamic reorganization of the cytoskeleton is essential for numerous cellular processes including leukocyte migration. This process presents a substantial bioenergetic challenge to migrating cells as actin polymerization is dependent on ATP hydrolysis. Hence, migrating cells must increase ATP production to meet the increased metabolic demands of cytoskeletal reorganization. Despite this long-standing evidence, the metabolic regulation of leukocyte motility and trafficking has only recently begun to be investigated. In this review, we will summarize current knowledge of the crosstalk between cell metabolism and the cytoskeleton in leukocytes, and discuss the concept that leukocyte metabolism may reprogram in response to migratory stimuli and the different environmental cues received during recirculation ultimately regulating leukocyte motility and migration.
细胞骨架的动态重组对于包括白细胞迁移在内的许多细胞过程是必不可少的。这个过程对迁移细胞来说是一个巨大的能量挑战，因为肌动蛋白聚合依赖于 ATP 水解。因此，迁移细胞必须增加 ATP 的产生，以满足细胞骨架重组增加的代谢需求。尽管有这一长期存在的证据，但白细胞运动和运输的代谢调节直到最近才开始被研究。在这篇综述中，我们将总结细胞代谢与白细胞中细胞骨架之间相互作用的最新知识，并讨论白细胞代谢可能对迁移刺激做出反应并根据在再循环过程中接收到的不同环境信号进行重新编程的概念，最终调节白细胞的运动和迁移。
