Downey G P
Department of Medicine, University of Toronto, Ontario, Canada.
Curr Opin Immunol. 1994 Feb;6(1):113-24. doi: 10.1016/0952-7915(94)90042-6.
Motility is a complex process that depends on the coordination of many cellular functions, including the conversion of information from the environment into a series of coordinated responses that culminate in directed cell movement. Major advances have been made in the understanding of many functions involved in motility, such as transmembrane signaling events, leading to alterations in the actin cytoskeleton, and interactions between adhesion receptors and components of the cytoskeleton, providing a link between the extracellular and intracellular environments. Studies using yeast (Saccharomyces cerevisiae), slime molds (Dictyostelium discoideum) and nematodes (Caenorhabditis elegans) have advanced our understanding of the molecular biology of cytoskeletal proteins and have important implications for mammalian leukocyte motility.
运动是一个复杂的过程，它依赖于许多细胞功能的协调，包括将来自环境的信息转化为一系列协调反应，最终导致细胞定向移动。在对运动所涉及的许多功能的理解方面已经取得了重大进展，例如跨膜信号转导事件，导致肌动蛋白细胞骨架的改变，以及粘附受体与细胞骨架成分之间的相互作用，从而在细胞外和细胞内环境之间建立联系。使用酵母（酿酒酵母）、黏菌（盘基网柄菌）和线虫（秀丽隐杆线虫）进行的研究，增进了我们对细胞骨架蛋白分子生物学的理解，并且对哺乳动物白细胞的运动具有重要意义。
