Lee Seung Won, Park Ki Nam
Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea.
Laryngoscope. 2018 Aug;128(8):1893-1897. doi: 10.1002/lary.27140. Epub 2018 Feb 16.
This study compared and assessed long-term voice outcomes when thyroidectomy-related unilateral vocal fold paralysis (VFP) was managed using injection laryngoplasty (IL) and recurrent laryngeal nerve reinnervation (RLNR).
Prospective clinical study.
A prospective clinical trial was performed from March 2005 to January 2016 at Soonchunhyang University Bucheon Hospital (Bucheon, South Korea). Nineteen patients who underwent ansa cervicalis to RLNR or direct reinnervation, and 43 patients who underwent IL to treat thyroidectomy-related unilateral VFP, were enrolled.
All voice parameters exhibited statistically significant improvement 12 months post-IL, which persisted for 24 and 36 months (P < 0.05). However, at 36 months post-IL, some voice parameters had deteriorated relative to the values at 24 months post-IL. After RLNR, all voice parameters exhibited statistically significant improvement after 12 months, and the improvements remained stable until 36 months postsurgery without deterioration of voice parameters (P < 0.05). At 36 months, RLNR provided better voice results than IL (P < 0.05).
Both RLNR and IL yielded statistically significant voice improvements at 36 months postoperatively. However, after 36 months, RLNR provided better results than IL.
本研究比较并评估了采用注射喉成形术（IL）和喉返神经再支配术（RLNR）治疗甲状腺切除术后相关单侧声带麻痹（VFP）的长期嗓音结果。
前瞻性临床研究。
2005年3月至2016年1月在韩国顺天乡大学富川医院（富川）进行了一项前瞻性临床试验。纳入了19例行颈袢至喉返神经再支配术或直接再支配术的患者，以及43例行注射喉成形术治疗甲状腺切除术后相关单侧声带麻痹的患者。
注射喉成形术后12个月，所有嗓音参数均有统计学意义的改善，并持续至24个月和36个月（P < 0.05）。然而，在注射喉成形术后36个月时，一些嗓音参数相对于术后24个月时有所恶化。喉返神经再支配术后，所有嗓音参数在12个月后均有统计学意义的改善，且改善情况一直稳定至术后36个月，嗓音参数未恶化（P < 0.05）。在36个月时，喉返神经再支配术的嗓音结果优于注射喉成形术（P < 0.05）。
喉返神经再支配术和注射喉成形术在术后36个月时均使嗓音有统计学意义的改善。然而，36个月后，喉返神经再支配术的效果优于注射喉成形术。
3。《喉镜》，2018年，第1893 - 1897页。
