Mahmud Khairil Afif, Azman Mawaddah, Muhammad Rohaizak, Mat Baki Marina
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz UKM, Level 9, Department of Otorhinolaryngology, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur, Malaysia.
Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz UKM, Kuala Lumpur, Malaysia.
Sci Rep. 2025 Feb 25;15(1):6811. doi: 10.1038/s41598-025-86642-3.
Early intervention is the current paradigm shift in the management of recurrent laryngeal nerve (RLN) injury post thyroidectomy and parathyroidectomy. Thus, an integrated clinical pathway is needed to enable early detection of RLN injury. A prospective longitudinal study was conducted from 2015 until 2021 in a single tertiary centre. A clinical pathway was developed where routine perioperative laryngeal assessments were implemented for all patients who underwent thyroidectomy and parathyroidectomy. Following an RLN injury, early surgical intervention was performed for unilateral vocal fold paralysis (UVFP). Data on patient demographics, risk factors, timing of RLN injury detection and type of intervention received were recorded in a proforma and analysed. 397 patients were included, involving 660 nerves at risk. The incidences of permanent RLN injury following thyroidectomy and parathyroidectomy were 5% and 1.8% respectively. The usage of intraoperative neuromonitoring was the only significant factor that affected the RLN injury according to multivariate analysis. 15% of RLN injuries were detected intraoperatively and 98% within two days. 70% of patients with UVFP received intervention in less than two weeks. The integrated clinical pathway has improved the validity of RLN injury incidence. It allows early detection of RLN injury and facilitates immediate intervention.
早期干预是目前甲状腺切除术和甲状旁腺切除术后喉返神经(RLN)损伤管理中的范式转变。因此,需要一个综合临床路径来实现对RLN损伤的早期检测。2015年至2021年在一家单一的三级中心进行了一项前瞻性纵向研究。制定了一条临床路径,对所有接受甲状腺切除术和甲状旁腺切除术的患者进行围手术期常规喉部评估。发生RLN损伤后,对单侧声带麻痹(UVFP)进行早期手术干预。在一份表格中记录并分析了患者人口统计学、风险因素、RLN损伤检测时间和接受的干预类型等数据。纳入了397例患者,涉及660条有风险的神经。甲状腺切除术后和甲状旁腺切除术后永久性RLN损伤的发生率分别为5%和1.8%。根据多变量分析,术中神经监测的使用是影响RLN损伤的唯一显著因素。15%的RLN损伤在术中被检测到,98%在两天内被检测到。70%的UVFP患者在不到两周的时间内接受了干预。综合临床路径提高了RLN损伤发生率的有效性。它允许早期检测RLN损伤并促进立即干预。