随机试验：极早产儿及早或延迟经口喂养的效果比较。
Randomized trial of earlier versus later oral feeding in very premature infants.
机构信息
Children's Memorial Hermann Hospital, Houston, TX, USA.
Department of Neonatal-Perinatal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
出版信息
J Perinatol. 2018 Jun;38(6):687-692. doi: 10.1038/s41372-018-0058-2. Epub 2018 Feb 16.
OBJECTIVES
To ascertain if earlier oral feeding initiation results in earlier attainment of full oral feedings/hospital discharge in very premature infants.
STUDY DESIGN
Eligible infants born at <29 weeks' gestation were randomized at 30 weeks' postmenstrual age (PMA) to initiate oral feedings at 30 weeks' PMA (Earlier Oral Feeding Group) versus 33 weeks' PMA (Later Oral Feeding Group).
RESULTS
Thirty-four infants were randomized to the Earlier Oral Feeding Group and 32 to the Later Oral Feeding Group. There were no significant differences in our primary outcomes of PMA at full oral feedings (mean difference -0.5 weeks, 95% CI: -2.2 to +1.2 weeks) or hospital discharge (mean difference -0.2 weeks, 95% CI: -1.8 to +1.4 weeks).
CONCLUSIONS
Initiating oral feeding attempts in very premature infants at 30 weeks' PMA does not result in earlier attainment of full oral feedings or discharge but is safe for infants who are not severely tachypneic or receiving positive pressure.
目的
确定极早产儿更早开始经口喂养是否能更早达到完全经口喂养/出院。
研究设计
在 29 周妊娠后，选择胎龄 <29 周的早产儿，在 30 周校正胎龄（PMA）时随机分为 30 周 PMA 时（早期经口喂养组）开始经口喂养与 33 周 PMA 时（晚期经口喂养组）开始经口喂养。
结果
34 例婴儿被随机分配到早期经口喂养组，32 例婴儿被分配到晚期经口喂养组。我们的主要结局，即完全经口喂养时的 PMA（平均差异-0.5 周，95%CI：-2.2 至+1.2 周）或出院时的 PMA（平均差异-0.2 周，95%CI：-1.8 至+1.4 周）均无显著差异。
结论
在 30 周 PMA 时开始对极早产儿进行经口喂养尝试不会更早达到完全经口喂养或出院，但对于没有严重呼吸急促或接受正压通气的婴儿是安全的。
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